Mortezaali Razzaghi's research sits at the interface of structural biology and biophysics. Razzaghi's uses high-resolution methods; notably cryo-electron microscopy (cryo-EM) and X-ray crystallography to elucidate macromolecular structures and dynamics, revealing mechanistic insights into biomolecular function. My contributions include characterizing protein-nucleic acid structures and advancing our understanding of structure–function relationships (SAR) in key biological systems, especially on molecular machines supporting genome stability.

Key publications:

Honda M, Razzaghi M, Gaur P, Malacaria E, Marozzi G, Di Biagi L, Aiello FA, Paintsil EA, Stanfield AJ, Deppe BJ, Gakhar L, Schnicker NJ, Spies MA, Pichierri P, Spies M. The RAD52 double-ring remodels replication forks restricting fork reversal. Nature. 2025 May, 641(8062), 512-519. PubMed PMID 40175552.
Link https://rdcu.be/eQDR1

Granger SL, Sharma R, Kaushik V, Razzaghi M, Honda M, Gaur P, Bhat DS, Labenz SM, Heinen JE, Williams BA, Tabei SMA, Wlodarski MW, Antony E, Spies M. Human hnRNPA1 reorganizes telomere-bound replication protein A. Nucleic Acids Res. 2024 Nov 11, 52(20), 12422-12437. PubMed Central PMCID PMC11551749.
Link https://doi.org/10.1093/nar/gkae834

For the full list of publications, please check the Google Scholar link.